Indications: benign gastric, duodenal ulceration, and in

Helicobacter pylori eradication (combination therapy). Cautions: Hepatic dysfunction, encephalopathy was reported with prolong use.

Contra-indications: renal impairment; pregnancy.

Side effect: nausea and vomiting and may darken tongue and blacken faeces.

Drug Interactions: It reduces absorption of tetracyclines. Dose: 2 tablets twice daily or 1 tablet 4 times daily¸30 minutes before meal, taken for 28 days followed by further 28 days if necessary. The course may be repeated after intervals of one month. Not recommended for children.