Indications: adjunct to diet and statin in type IIb or III hypertriglyceridaemia; adjunct to diet in type IV hypertriglyceridaemia; adjunct in secondary prevention in those who have had a myocardial infarction in the preceding 3 months.

Cautions: haemorrhagic disorders, anticoagulant treatment (bleeding time increased)

Hepatic impairment: monitor liver function

Pregnancy: manufacturers advise use only if potential benefit outweighs risk—no information available.

Breast-feeding: manufacturers advise avoid—no information available.

Side Effects: dyspepsia, nausea; less commonly taste disturbances, abdominal pain, gastritis, dizziness; rarely hepatic disorders, headache, hyperglycaemia, acne, rash; very rarely gastro-intestinal haemorrhage, hypotension, nasal dryness, urticaria, and increased white cell count.

Dose: hypertriglyceridaemia, initially 2 capsules daily with food, increased if necessary to 4 capsules daily Secondary prevention after myocardial infarction, 1 capsule daily with food.