This is a bile acid-binding resin.

Indications: hypercholesterolemia (type II a) in patients who have not responded to diet and other measures; primary prevention of coronary heart disease in men 35 to 59 years of age; pruritis associated with primary billiary obstruction & cirrhosis; diarrhoeal disorders..

Cautions: supplements of fat-soluble vitamins and of folic acid may be required with high doses, particularly in children, may reactivate peptic ulceration; hepatic impairment, pregnancy, breast-feeding.

Contra-indications: complete biliary obstruction.

Side Effects: Since it is not absorbed from GI tract, hence side effect are GI like nausea, vomiting, GI discomfort, constipation.

Dose: usually 12-24 g daily in liquid in single or divided doses; up to 36 g daily in resistant case.