This is an antithrombotic drug which decreases the platelet adhesiveness, thus inhibiting thrombus formation on the arterial side of the circulation; it has little effect on venous thromboembloism.

Indications: modifications of platelet function; all forms of coronary insufficiency; prophylaxis and after treatment of myocardial infarction; acute myocardial infarction without circulatory collapse; basic therapy in cardiac failure; cerebrovascular thrombosis; thrombosis of peripheral arteries; prevention of deep venous thrombosis of the leg.

Cautions: may exacerbate migraine, hypotension; myasthenia gravis; breast feeding; recent myocardial infarction, heart failure or aortic stenosis.

Side effect: gastrointestinal disturbances, dizziness, myalgia, throbbing headache, hot flushes and tachycardias, hypersensitivity.

Dose: by mouth, 300-600 mg daily in 3-4 divided doses before food.