Indications: prophylaxis and treatment of angina; left ventricular failure.

Cautions: hypotensive conditions, severe hepatic or renal impairment, hypothyroidism, head trauma, cerebral haemorrhage.

Contra-indications: Nitrate hypersensitivity, hypotension and hypovolemia, hypertrophic obstructive cardiomyopathy, aortic stenosis, mitral stenosis, constrictive pericarditis, marked anemia, closed-angle glaucoma.

Side Effects: throbbing headache, flushing, dizziness, postural hypotension, tachycardia.

Dose: sublingually, 0.3-1 mg repeated, as required. By IV infusion, 10-200 mcg/minute.

Plaster, once daily on lateral chest wall, upper arm, thigh, abdomen or shoulder; siting replacement patch on different area.