This is an angiotensin-converting enzyme inhibitor. Indications: hypertension; congestive heart failure in association, or not, with diuretic, with or without digitalis. Cautions: (See ACE-inhibitors); severe hepatic impairment.

Contra-indications: (See ACE-inhibitors)

Side Effects: (See ACE-inhibitors); asthenia, mood and sleep disturbances.

Renal impairment: ; max. initial dose 2.5mg once daily if eGFR 30–60 ml/minute/1.73m2; 2.5mg once daily on alternate days if eGFR 15–30 ml/minute/1.73m2

Dose Hypertension, initially 5mg once daily in the morning for 1 month, subsequently adjusted according to response; if used in addition to diuretic, in elderly, in renal impairment, in cardiac decompensation, or in volume depletion, initially 2.5mg once daily; max. 10mg daily. Heart failure (adjunct), initially 2.5mg once daily in the morning under close medical supervision, increased after 2 weeks to max. 5mg once daily if tolerated. Following myocardial infarction or revascularisation, initially 5mg once daily in the morning increased after 2 weeks to 10mg once daily if tolerated; ELDERLY 2.5mg once daily for 1 week, then 5mg once daily for 1 week, thereafter increased to 10mg once daily if tolerated.

Note : For hypertension not adequately controlled by perindopril alone