is for the prophylaxis and treatment of acute hyperuricaemia, before and during initiation of chemotherapy, in patients with haematological malignancy and a high tumour burden at risk of rapid lysis.

Indications: prophylaxis and treatment of acute hyperuricaemia with initial chemotherapy for haematological malignancy.

Cautions: monitor closely for hypersensitivity; atopic allergies; may interfere with test for uric acid.

Contra-indications: G6PD deficiency,

Pregnancy: & Breast-feeding: Avoid

Side Effects: fever; less commonly nausea, vomiting, diarrhoea, headache, hypersensitivity reactions (including rash, bronchospasm and anaphylaxis); haemolytic anaemia, methaemoglobinaemia.

Dose: By intravenous infusion, 200 micrograms/kg once daily for up to 7 days according to plasma-uric acid concentration.