Indications: inhibits the activity of interleukin-1. Anakinra (in combination with methotrexate) is for the treatment of rheumatoid arthritis which has not responded to methotrexate alone; it is not, however, recommended for routine management of rheumatoid arthritis.

Cautions: predisposition to infection; history of asthma

Contra-indications: neutropenia, renal impairment caution if eGFR 30–50 ml/minute/1.73 m2; avoid if eGFR less than 30 ml/minute/1.73 m2.

Pregnancy & Breast-feeding: avoid

Side Effects: injection-site reactions; headache; infections, neutropenia (see also cautions), and antibody formation; also reported malignancy.

Dose: By subcutaneous injection, ADULT over 18 years, 100 mg once daily.