This is a progestogen

Indications: endometriosis, premenstrual syndrome, dysmenorrhoea, dysfunctional uterine bleeding, postponement of menstruation, contraception, HRT, malignant diseases.

Cautions: same as for dydrogesterone; breast feeding.

Contra-indications: same as for dydrogesterone; pregnancy.

Side Effects: same as for dydrogesterone; rare with dose below 15 mg daily. Headaches and depression occur occasionally.

Dose: endometriosis, 10 mg daily starting on 5th day of cycle (increased if spotting occurs to 25 mg daily in divided doses to prevent breakthrough bleeding) for at least 6 months.

Dysfunctional uterine bleeding, menorrhagia, 5 mg 3 times daily for 10 days to arrest bleeding; to prevent bleeding, 5 mg twice daily from 19th to 26th day of cycle. Dysmenorrhea, 5 mg 3 times daily from 5th to 25th day for 3-4 cycles.

Premenstrual syndrome, 5 mg 2-3 times daily from 19th to 26th day for several cycles (not recommended since there is no physiologic basis for such treatment).

Postponement of menstruation, 5 mg 3 times daily starting 3 days before anticipated onset (menstruation occurs 2-3 days after stopping).