Indications: broad spectrum bactericidal agent for upper and lower, complicated and uncomplicated acute and chronic urinary tract infections; acute bacterial gastro- enteritis caused by sensitive bacteria; gonococcal urethritis and/or cervicitis caused by both penicillinase and non-penicillinase producing Neisseria gonorrhoea; for the prophylaxis of sepsis in patients with profound neutropenia.

Caution history of convulsions; pregnancy; nursing mothers.

Contra-indications: hypersensitivity to the drug or any chemically related quinolone antibacterial.

Side Effects: gastro-intestinal, neuropsychiatry and skin reactions; rarely, anorexia, sleep disturbances, depression.

Dose: Urinary-tract infections, 400 mg twice daily for 7– 10 days (for 3 days in uncomplicated lower urinary-tract infections).

Chronic relapsing urinary-tract infections, 400 mg twice daily for up to 12 weeks; may be reduced to 400 mg once daily if adequate suppression within first 4 weeks Chronic prostatitis, 400 mg twice daily for 28 days.