This is a third generation cephalosporin.

Indications: septicaemia, endocarditis and meningitis, except those due to Listeria monocytogenes, gonorrhoea; surgical prophylaxis; Haemophilus epiglottitis and meningitis.

Caution allergy to cephalosporins or penicillin.

Side Effects: allergic reaction; digestive disorders; transient hematological changes; hepatic function changes; phlebitis after injection.

Dose: by IM or IV injection or IV infusion, 1 g every 12 hours increased in severe infections such as meningitis to 8 g daily in 4 divided doses. Up to 12 g in 3-4 divided doses may be given. Neonate, 50 mg/kg in 2-4 divided doses increased to 150-200 mg/kg daily in severe infections.

Child, 100-150 mg/kg daily in 2-4 divided doses increased to 200 mg/kg daily in very severe infections Gonorrhoea, 500 mg as a single dose.