Indications: infections due to Gram-negative and Gram- positive microorganisms; septicaemia; ; meningitis; abdominal infections (peritonitis, infections of the biliary and gastro-intestinal tracts); infections of the bones, joints, soft tissue, skin and of wounds; infections in patients with impaired defense mechanisms; renal and urinary tract infections; respiratory tract infections, particularly pneumonia, and ear, nose and throat infections; genital tract infections including gonorrhea and perioperative prophylaxis of infections.

Caution anaphylactic shock cannot be ruled out; shadows suggesting sludge have been detected by sonograms of the gall bladder, but this is reversible upon discontinuation of therapy or completion; caution in hyperbilirubinemic neonates, especially prematures; blood picture should be checked regularly during prolonged treatment.

Contra-indications: known hypersensitivity to the cephalosporins; neotaes with jaundice.

Side Effects: gastro-intestinal complaints; skin reactions; hematological changes and other rare side effects like headache, and mycosis of the genital tract; phlebitis may occur rarely after administration and it can be prevented by slow injection (two to four minutes).

Dose: by deep IM injection on IV injection over at least 2-4 minutes or by IV infusion, adults and children over 12 years, 1-2 g once daily.

In severe cases or infections caused by moderately sensitive organisms, up to 4 g once daily.

Uncomplicated gonorrhoea, by deep IM injection, 250 mg as a single dose.

Neonates (up to 2 weeks), by IV infusion over 60 minutes, 20-50 mg/kg daily (max. 50 mg/kg daily).

Child 3 weeks-12 years, 20-80 mg/kg daily.

Child with body weight more than 50 kg, adult dose should be given.

IV doses of 50 mg more /kg should be given by infusion over at least 30 minutes.

IM doses over 1 g divided between more than one site.

Pregnancy: Not known to be harmful

Breast feeding: Present in milk in low concentration