Indications: ulcerative colitis, management of active Crohn's disease. Rectally used to treat distal ulcerative colitis, proctosigmoiditis, or proctitis.

Cautions: renal disorders; raised blood urea or proteinuria; pericarditis; Pancreatitis, pregnancy, breast feeding.

Contra-indications: sensitivity to salicylates; moderate and severe renal impairment; hepatic impairment, children under 2 years of age.

Side effect: cramping, acute abdominal pain, bloody diarrhea; vomiting, nausea, headache; depression of bone marrow, chest pain, shortness of breath, pancreatitis and preicarditis should be considered, sore throat, hemorrhoids, blood disorders, renal dysfunction, skin reactions (including lupus erythematosus- like syndrome, Stevens- Johnson syndrome), alopecia.

Dose: Adult (usual course of therapy is 3-8 weeks): Orally: treatment of ulcerative colitis, initial: 2 tablets 3 times / days for 6 weeks, maintenance of remission of ulcerative colitis, 1.6 g / day in divided doses.

Rectally: one supp. (500mg) twice daily. Some patients may require rectal and oral therapy concurrently.