Indications: nausea and vomiting particularly in gastro intestinal disorders, during treatment with cytotoxic drugs or radiotherapy, and post-operative conditions; migraine. Use in patients below 20 years of age is restricted to severe intractable vomiting of unknown cause; aid to gastrointestinal intubation; pre-medication.

Cautions: renal impairment, elderly, young adults and children (measure dose accurately); may mask underlying cause such as cerebral irritation; porphyria.

Contra-indications: gastro-intestinal obstruction, perforation or haemorrhage; 3–4 days after gastro- intestinal surgery; phaeochromocytoma; breast-feeding.

Side Effects: extrapyramidal effects (especially in children and young adults), hyperprolactinaemia, occasionally tardive dyskinesia on prolonged administration; drowsiness, restlessness, diarrhoea, depression, neuroleptic malignant syndrome, rashes, pruritus, oedema; cardiac conduction abnormalities reported following intravenous administration; rarely methaemoglobinaemia (more severe in G6PD deficiency).

Dose: by mouth, IM and IV injection, up to 10 mg (5 mg up to the age of 20 years^ 3 times dany. Child, up to 1 year, 1 mg twice daily; 1-3 years, 1 mg 2-3 times daily; 3-5 years, 2 mg 2-3 times daily; 5-9 years, 2.5mg 3 times.

daily; 9-14 years, 5 mg 3 times daily.

A daily dose of 500 mcg/kg should not be exceeded particularly for patients under 20 years.

IV Infusion, nausea and vomiting associated with cytotoxic drugs, up to 2 mg/kg every 2 hours up to a max. of 10 mg/kg/24 hours.

The initial dose should be given before starting cytotoxic treatment. For radiological examinations, as a single dose by IM or IV injection 5-10 minutes before examination, 10-20 mg (10 mg for ages 15-19 years) Child under 3years, 1 mg 3-5 years, 2 mg 5-9 years, 2.5 mg 9-14 years, 5 mg By continuous IV infusion (preferred route), initially before starting the chemotherapy, 2-4 mg/kg over 15-30 minutes, then 3-5 mg /kg over 8-12 hours; max. in 24 hours, 10 mg/kg.

By intermittent IV infusion, initially before starting the chemotherapy, up to 2 mg/kg over at least 15 minutes then up to 2 mg/kg over at least 15 minutes every 2 hours; max, in 24 hours, 10 mg/kg.