It is antilipemic agent, HMG-CoA reductase inhibitor

Indications: Used with dietary therapy for the following, primary hypercholesterolaemia, heterozygous familial hypercholesterolaemia, homozygous familial hypercholesterolaemia or combined Hyperlipidaemia in patients who have not responded to diet and other appropriate measures, prevention of cardiovascular events in patients with type 2 diabetes.

Cautions: Should be used with caution in those with history of liver disease or with a high alcohol intake. Hypothyroidism should be managed before treatment starting. Liver – function tests should carried out before and within1-3 months of starting treatment and thereafter at intervals of 6 months for 1 year. Should be used with caution in those with risk factor for myopathy or rhabdomyolysis.

Contra-indications: Hypersensitivity to atorvastatin or any component of the formulation, active liver disease, pregnancy, breast-feeding, unexplained persistent elevations of serum transaminases.

Side Effects: Headache, abdominal pain, flatulence, constipation, diarrhea, nausea, vomiting, rash, chest pain angina, insomnia, dizziness, hypoaesthesia, arthralgia, back pain, anorexia, malaise, weight gain, alopecia, urinary tract infection, sinusitis, pharyngitis, bronchitis, rhinitis, flu- like syndrome.

Dose: Primary hypercholesterolaemia and combined hyperlipidaemia, 10 mg once daily, if necessary, may be increased at intervals of at least 4 weeks to max. 80 mg once daily.Child 10-17 years (females >1 year postmenarche) 10 mg once daily (max. 20 mg/ day), prevention of cardiovascular events in type 2 diabetes, 10 mg once daily. No dosing adjustment required in renal impairment.