Indications: as an antidote for heparin

Cautions: increased risk of allergic reaction to protamine (includes previous treatment with protamine or protamine insulin, allergy to fish, men who are infertile or who have had a vasectomy)

Side Effects: nausea, vomiting, lassitude, flushing, hypotension, bradycardia, dyspnea; hypersensitivity reactions (including angioedema, anaphylaxis) reported.

Dose: by intravenous injection over approx. 10 minutes, 1 mg neutralizes 80 – 100 units of heparin when given within 15 minutes of heparin; if longer time, less protamine required as heparin is rapidly excreted; max. 50 mg.