This is a low-molecular weight (LMW) heparin

Indications: prophylaxis of venous thromboembolic disease after certain procedures; prevention of thrombus formation in the extra-corporeal circulation during hemodialysis; treatment of established deep vein thrombosis; treatment of unstable angina and non Q-wave myocardial infarction during the acute stage, in combination with aspirin.

Cautions: do not inject intramuscularly.

Contra-indications: allergic reactions; major clotting disorders; history of thrombocytopenia; active gastro- intestinal bleeding; acute infectious endocarditis; severe renal impairment; hemorrhagic vascular cerebral stroke; uncontrolled arterial hypertension; breastfeeding.

Side Effects: (See Heparin)

Dose: every 1 mg (0.01 ml) corresponds to 100 anti-Xa i.u.

In prophylaxis and curative treatment, it should be given by subcutaneous route.

During haemodialysis it should be given by extra vascular route.

Prophylaxis of venous thrombosis, 20 mg once daily. Highly thrombogenic risk surgery (e.g. orthopedic surgery), 40 mg once daily.

Treatment should continue for 7-10 days. Prevention of extra-corporeal thrombus during hemodialysis, 1mg/kg.

Treatment of established deep vein thrombosis, 1 mg/kg subcutaneous every 12 hours. Treatment period should not exceed 10 days.

Treatment of unstable angina and non-Q-wave myocardial infarction, 1 mg/kg SC every 12 hours for a period of 2-8 days. It should be administered concurrently with oral aspirin (100-325 mg daily).