Indications: intermediate-duration, non-depolarising neuromuscular blocking agent for IV use. Used as an adjunct to general anesthesia, or sedation in the Intensive Care Unit (ICU) to relax skeletal muscles and to facilitate tracheal intubation and mechanical ventilation.

Cautions: hypersensitivity to other neuro-muscular blocking agents due to cross-reactivity; myasthenia gravis and other forms of neuromuscular disease.

Dose: In adult intubation, by IV bolus injection, 150mcg/kg.

Maintenance, 30 mcg/kg provides 20 minutes of additional effective neuromuscular block.

Child, 2-12 years, 100 mcg/kg.

Maintenance, 20 mg/kg provides 9 minutes of additional effective neuromuscular block.