Indications: raised intra-ocular pressure in ocular hypertension, open-angle glaucoma, pseudo-exfoliative glaucoma adjunct to beta-blocker

Cautions: hepatic impairment; systemic absorption follows topical application; history of renal calculi; chronic corneal defects, history of intra-ocular surgery;

Contra-indications: severe renal impairment of hyperchloraemic acidosis, pregnancy and breast-feeding.

Side-Effects: ocular burning, stinging and itching, blurred vision, lacrimation, conjunctivitis, super-facial punctuate keratitis, eyelid inflammation and crusting anterior uveitis, transient myopia, corneal oedema, iridocyclitis, headache, dizziness, paraesthesia, asthenia, sinusitis, rhinitis, nausea, hypersensitivity reactions (including urticaria, angio-edema, bronchospasm); bitter taste, epistaxis, urolithiasis.

Dose: for raised intra-ocular pressure in open-angle glaucoma, or pseudoexfoliative glaucoma when beta- blockers alone not adequate, apply twice daily.