Indications: symptomatic relief of gastro-intestinal or genito-urinary tract disorders characterized by smooth muscle spasm, bowel colic and excessive respiratory secretions.

Contra-indications: hypersensitivity to scopolamine or any component of the formulation of narrow angle glaucoma, GI or GU obstruction, acute hemorrhage, paralytic ileus, thyrotoxicosis, tachycardia secondary to cardiac insufficiency, myasthenia gravis.

Precautions: use with caution with hepatic or renal impairment pregnancy, use with caution in patient with GI obstruction, use with caution in Down syndrome, in children and elderly.

Side effect: anticholinergic side effects including dry mouth, dryness of skin, tachycardia, and urinary retention, constipation, dilatation of the pupil with loss of accommodation, photophobia.

Drug Interactions: decreased effect of paracetamol, levodopa, ketoconazole, digoxin, riboflavin, increased toxicity when given with other anticholinergic agents. Dose: By mouth, adult dose is 20 mg 4 times daily; child 6-12 years, 10 mg 3 times daily.

Irritable bowel syndrome, 10 mg 3 times daily; increased if necessary up to 20 mg 4 times daily. By IM or IV injection, acute spasm and spasm in diagnostic procedures, 20 mg repeated after 30 minutes if necessary.