This is an enzyme used to render the tissues more easily permeable to injected fluids as in SC infusions.

Indications: enhance permeation of SC or IM injections, local anesthetics and SC infusions; promote resorption of excess fluids and blood.

Cautions: infants and elderly

Contra-indications: do not apply direct to cornea; sites of infection or malignancy; swelling sites of bites or stings; not for IV use.

Side Effects: occasional severe allergy.

Dose: With subcutaneous or intramuscular injection, 1500 units dissolved directly in solution to be injected (ensure compatibility)

With local anaesthetics, 1500 units mixed with local anaesthetic solution (ophthalmology, 15 units/ml) Hypodermoclysis, 1500 units dissolved in 1ml water for injections or 0.9% sodium chloride injection, administered before start of 500–1000ml infusion fluid; Extravasation or haematoma, 1500 units dissolved in 1ml water for injections or 0.9% sodium chloride injection, infiltrated into affected area (as soon as possible after extravasation)