Indications: hypertension, angina and as an adjunct in heart failure.

Cautions, contra-Indications and Side Effects:

(see under Propranolol Hydrochloride); in heart failure monitor clinical status for 4 hours after initiation (with low dose) and ensure heart failure not worsening before increasing each dose; psoriasis; hepatic impairment.

Contra-indications: (see under Propranolol Hydrochloride); acute or decompensated heart failure requiring intravenous inotropes; sino-atrial block.

Side Effects: (see under Propranolol Hydrochloride)

Dose: hypertension and angina, usually 10 mg once daily (5mg may be adequate in some patients); max. 20 mg daily.

Adjunct in stable moderate to severe heart failure, initially 1.25 mg once daily in the morning for 1 week, then, if well tolerated, increased to 2.5 mg once daily for 1 week, then 3.75 mg once daily for 1 week, then 5 mg once daily for 4 weeks, then 7.5mg once daily for 4 weeks, then 10 mg once daily; max. 10 mg daily.