Indications: is a uricosuric drug that reduces plasma concentrations of uric acid by blocking renal tubular reabsorption. It has been suggested that benzbromarone may also increase the intestinal elimination of uric acid. It has been used to treat hyperuricaemia including that associated with chronic gout.

Cautions:. administer prophylactic colchicine or NSAID (not aspirin or salicylate)

Contra-indications: not used to treat acute attacks of gout

Side Effects: rashes, fever (withdraw therapy). If the rash is mild the drug can be re-introduced with caution and discontinued immediately if rash recur; malaise, vertigo, headache, symptomless xanthine deposits in muscle, alopecia, hepatotoxicity.

Dose: 50 to 200 mg daily.

An NSAID or colchicine should be given initially to reduce the risk of precipitating acute gout. An adequate fluid intake should be maintained.

Lower doses of benzbromarone (20 mg) have also been used in the form of a combination product with allopurinol.