Indications: Pain and inflammation in rheumatic disease (including Still's disease) and other musculoskeletal disorders; acute gout; post-operative pain.

Cautions: breast-feeding.

Contra-indications: porphyria; Intravenous use. Additional contra-indications include concomitant NSAID or anticoagulant use (including low-dose heparin), history of haemorrhagic diathesis, history of confirmed or suspected cerebrovascular bleeding, operations with high risk of haemorrhage, history of asthma, moderate or severe renal impairment, hypovolaemia, dehydration.

Side Effects: diarrhea, constipation, gas or bloating, headache, dizziness, ringing in the ears, unexplained weight gain, excessive tiredness, lack of energy, upset stomach, loss of appetite, itching, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms, fever, blisters, rash, hives, swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs, difficulty breathing or swallowing, hoarseness pale skin, fast heartbeat, cloudy, discolored, or bloody urine back pain, difficult or painful urination; suppositories may cause rectal irritation; injection site reactions.

Dose: By mouth, 75–150mg daily in 2–3 divided doses By deep intramuscular injection into the gluteal muscle, acute exacerbations of pain and postoperative pain, 75mg once daily (twice daily in severe cases) for max. of 2 days Ureteric colic, 75mg then a further 75mg after 30 minutes if necessary.

By intravenous infusion (in hospital setting), 75mg repeated if necessary after 4–6 hours for max. 2 days. Prevention of postoperative pain, initially after surgery 25–50mg over 15–60 minutes then 5mg/hour for max. 2 days.

By rectum in suppositories, 75–150mg daily in divided doses.

Max. total daily dose by any route 150mg.

child 1–12 years, juvenile arthritis, by mouth or by rectum, 1–3mg/kg daily in divided doses (25mg e/c tablets, 12.5mg and 25mg suppositories only)

child 6–12 years, postoperative pain, by rectum, 1– 2mg/kg daily in divided doses (12.5mg and 25mg suppositories only) for max. 4 days.