Indications: urothelial toxicity associated with the use of cyclophosphamide or ifosfamide. (urothelial toxicity is manifested by haemorrhagic cystitis and is caused by the metabolite acrolein).

Contra-indications: hypersensitivity to thiol-containing compounds.

Side effect: above max. therapeutic doses, gastro-intestinal disturbances, fatigue, headache, limb pains, depression, irritability, hypotension and tachycardia, and skin rash.

Dose: given simultaneously with cyclophosphamide or ifosfamide, and further doses are given orally or intravenously 4 and 8 hours after treatment. For oral administration, the contents of ampoule are taken in fruit juice.