Drug Information
Drug Generic Name | TACROLIMUS |
Drug Class | CORTICOSTEROIDS AND OTHER IMMUNOSUPPRESSANTS |
Chapter | Malignant Disease & Immunosuppression |
This is a potent macrolide immunosuppressant derived from Streptomyces tsukabaensis, and has actions similar to those of cyclosporine. Indications: prophylaxis organ rejection in patients receiving allogenic liver or kidney transplants. Used in conjunction with adrenal corticosteroids. Cautions: Cardiomyopathy has been reported in children given tacrolimus after transplantation. Patients should be monitored carefully by echocardiography for hypertrophic changes; dose reduction or discontinuation should be considered if these occur. Monitor visual status, blood glucose, hematological and neurological parameters. Contra-indications: hypersensitivity to macrolides; hypersensitivity (risk of anaphylaxis) to polyoxyl 60 hydrogenated castor oil, which is present in the injection; avoid concurrent use with cyclosporine (additive nephrotoxicity). Side Effects: include gastrointestinal disturbances like dyspepsia, and inflammatory & ulcerative disorders; hepatic dysfunction, jaundice, bile duct and gall bladder abnormalities; hypertension; cardimyopathy. Dose: 100 – 300 mcg/kg daily in 2 divided doses orally; or by IV infusion over 24 hrs. 10 – 50 mcg/kg. |
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