This is a platinum-containing complex similar to cisplatin.

Indications: metastatic colorectal cancer in combination with fluorouracil and folinic acid; colon cancer.

Cautions: Monitor WBC with differential, Hb, platelet count, and blood chemistries (ALT, AST, bilirubin and creatinine) before each cycle.

Contra-indications: patients with pre-existing sensory neuropathies or to those with severe renal impairment; pregnancy & breast feeding.

Side Effects: similar to those of cisplatin but nausea and vomiting, and nephrotoxicity, seem to be less marked.

Peripheral neuropathy occurs in, of patients; pain, functional impairment and loss of tendon reflexes may develop.