This is a thiazide-like diuretic.

Indications: oedema, hypertension.

Cautions: serum electrolytes should be monitored to avoid fluid and/or electrolyte imbalance; may cause hypokalemia; elderly; pregnancy; concomitant use of frusemide; porphyria.

Contra-indications: breast-feeding; paediatric use.

Side Effects: dizziness; headache; muscle cramps; fatigue; joint pain and swelling; chest pain; rash; pruritis; anxiety; dry mouth; impotence.

Dose: edema, 5-10mg in the morning; increased if necessary to 20 mg daily.

Max. dose, 80mg daily.

Hypertension, initially, 5mg in the morning. Maintenance dose, 5mg on alternate day.