This is a bifunctional alkylating agent of the nitrogen mustard type.

Indications: chronic lymphocytic leukemia, malignant lymphomas including Hodgkin's disease, lymphosarcoma, giant follicular lymphoma.

Cautions: Hepatic impairment; porphyria.

Contra-indications: When rashes develop, discontinue drug and cyclophosphamide is substituted.

Side effect: bone marrow suppression; rarely severe rashes which may progress to Stevens - Johnson syndrome or toxic epidermal necrolysis.

Dose: Alone 5 – 10mg (200 mcg/kg) daily for 4 – 8 weeks; maintenance – 2 – 4mg daily.