Indications: benign prostatic hyperplasia

Cautions: decrease serum concentration of prostate cancer markers such as prostate-specific antigen.

reference values may need adjustment. Both dutasteride and finasteride are excreted in semen and use of a condom is recommended if sexual partner is pregnant or likely to become pregnant. Women of childbearing potential should avoid handling crushed or broken tablets of finasteride and leaking capsules of dutasteride.

Male breast cancer: Cases of male breast cancer have been reported. Patients or their carers should be told to promptly report to their doctor any changes in breast tissue such as lumps, pain, or nipple discharge.

Hepatic impairment: avoid in severe impairment—no information available.

Contra-indications: Diltiazem: Plasma concentration of dutasteride increased. Verapamil: Plasma concentration of dutasteride increased.

Side Effects: of dutasteride and finasteride include impotence, decreased libido, ejaculation disorders, and breast tenderness and enlargement.

Dose: 500 micrograms daily, review treatment at 3–6 months and then every 6–12 months (may require several months treatment before benefit is obtained)