This is a progestogen.

Indications: endometriosis, dysfunctional uterine bleeding, secondary amenorrhoea; breast cancer; contraception.

Cautions: disturbances of normal cycle and irregular bleeding may occur; breast feeding.

Contra-indications: Current deep vein thrombosis or pulmonary embolism, Migraine Headache with aura, Before evaluation of unexplained vaginal bleeding, past H/O breast cancer and no evidence of current disease for 5 years, active liver disease, H/O stroke, IHD, Diabetes with complications; pregnancy.

Side Effects: Menstrual irregularities (bleeding or amenorrhea or both), and nervousness; indigestion.

Dose: by mouth, 2.5-10 mg daily for 5-10 days beginning on 16th-21st day of cycle, repeated for 2 cycles in dysfunctional bleeding and 3 cycles in secondary amenorrhoea.

Mild to moderate endometriosis, beginning on first day of menstrual cycle, 10 mg three times a day for 90 consecutive days.

By deep IM injection, endometrial or renal carcinoma, 400-1000 mg per week.

Maintenance, if condition improved, 400 mg per month Breast carcinoma, 500 mg/day for 28 days.

Maintenance, 500 mg twice weekly.

By deep intramuscular injection, 150 mg within first 5 days of cycle or within first 5 days after parturition (delay until 6 weeks after parturition if breast-feeding); for long-term contraception, repeated every 12 weeks (if interval greater than 12 weeks and 5 days, rule out Pregnancy before next injection and advise patient to use additional contraceptive measures (e.g. barrier) for 14 days after the injection).