Indications: mineralocorticoid replacement in adrenocortical insufficiency; adrenal hyperplasia (given with hydrocortisone)

Cautions: diabetes mellitus, tuberculosis, and liver disease.

Contra-indications: pregnancy and breast feeding.

Side Effects: hypertension; sodium and water retention, potassium loss; Irritation, stomach upset, vomiting, headache, dizziness, insomnia, restlessness, depression, anxiety, acne, increased hair growth, easy bruising, irregular or absent menstrual periods, skin rash, swollen face and ankles, vision problems, cold or infection that last a long time, muscle weakness, melena, DM.

Dose: adrenocortical insufficiency, 50-300 mcg daily Child, 5 mcg/kg daily Adrenal hyperplasia, 50-100 (rarely 150) mcg daily.