This is an intermediate-acting insulin. ISOPHANE INSULIN

(Isophane Insulin Injection; Isophane Protamine Insulin Injection; Isophane Insulin (NPH)—intermediate acting) Additional information interactions (Insulin); renal impairment; pregnancy.

A sterile suspension of bovine or porcine insulin or of human insulin in the form of a complex obtained by the addition of protamine sulphate or another suitable protamine.

Indications: diabetes mellitus

Cautions: reduce dose in renal impairment.

Side Effects: see under Insulin; protamine may cause allergic reactions.

Dose: by SC injection according to requirements. It has an onset of action of approximately 1-2 hours, a maximal effect at 4-12 hours, and a duration of 16-35 hours.

It can be mixed with soluble insulin in the syringe.