Indications: adjunct in the treatment of Plasmodium vivax and P. ovale malaria (eradication of liver stages.

Cautions: G6PD deficiency (test blood; systemic diseases associated with granulocytopenia (e.g. rheumatoid arthritis, lupus erythematosus); Pregnancy and breast-feeding.

Side Effects: nausea, vomiting, anorexia, abdominal pain; less commonly methaemoglobinaemia, haemolytic anaemia especially in G6PD deficiency, leucopenia.

Dose: In P. vivax infection: adult dosage of 30 mg daily for 14 days and for P. ovale infection it is given in an adult dosage of 15 mg daily for 14 days.

Pregnancy: Third trimester: Neonatal haemolysis and methaemoglobinaemia