Drug Information
Drug Generic Name | ALBENDAZOL |
Drug Class | ANTIPROTOZOAL AND ANTIHELMENTHIC DRUGS |
Chapter | Infections |
Indications: is indicated for the treatment of the following infections: Neurocysticercosis is indicated for the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, Taenia solium. Hydatid Disease is indicated for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, Echinococcus granulosus. Cautions: Monitor theophylline levels if used concomitantly. Potential for bone marrow suppression, aplastic anemia & agranulocytosis. Pre-existing neurocysticercosis may be uncovered in patients treated with albendazole for other conditions, apparent by neurological symptoms (e.g. seizures, increased intracranial pressure, and focal signs); promptly treat w/ corticosteroid & anticonvulsant therapy. Contra-indications: Hypersensitivity to albendazole or benzimidazoles. Pregnancy: Use with caution if benefits outweigh risks. Breast-feeding: unknown, use caution Side Effects: Abnormal Liver Function Tests, Abdominal Pain, Nausea/Vomiting, Headache, Dizziness/Vertigo, Raised Intracranial Pressure, Meningeal Signs, Reversible Alopecia, Fever. Dose: Hydatid Disease: 60 kg or greater 400 mg twice daily, with meals 28-day cycle followed by a 14-day albendazole-free interval, for a total of 3 cycles. less than 60 kg 15 mg/kg/day given in divided doses twice daily with meals (max. total daily dose 800 mg). Note: When administering in the pre- or post-surgical setting, optimal killing of cyst contents is achieved when 3 courses of therapy have been given. Neurocysticercosis: 60 kg or greater 400 mg twice daily, with meals 8-30 days less than 60 kg 15 mg/kg/day given in divided doses twice daily with meals (max. total daily dose 800 mg) |
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