Indications: It is a protease inhibitors for treatment of HIV infection in combination with antiretroviral agents.

Cautions: ensure adequate hydration (risk of nephrolithiasis especially in children); patients at risk of nephrolithiasis (monitor for nephrolithiasis); avoid in porphyria.

Contra-indications: Pregnancy; breast-feeding

Side Effects: dry mouth, hypoaesthesia, dry skin, hyperpigmentation, alopecia, paronychia, interstitial nephritis (with medullary calcification and cortical atrophy in asymptomatic severe leucocyturia), nephrolithiasis (may require interruption or discontinuation; more frequent in children), dysuria, haematuria, crystalluria, proteinuria, pyuria (in children); haemolytic anaemia.

Dose: 800 mg every 8 hours; CHILD and ADOLESCENT 4– 17 years, 500 mg/m2 every 8 hours (max. 800 mg every 8 hours); CHILD under 4 years, safety and efficacy not established