Indications: invasive aspergillosis). invasive candidiasis empirical treatment of systemic fungal infections in patients with neutropenia.

Contra-indications: Hypersensitivity

Hepatic impairment: 70 mg on first day then 35 mg once daily in moderate impairment; no information available for severe impairment.

Pregnancy: manufacturer advises avoid unless essential—toxicity in animal studies.

Breast-feeding: present in milk in animal studies (manufacturer advises avoid).

Side Effects: nausea, diarrhoea, vomiting; dyspnea; headache; hypokalemia; arthralgia; rash, pruritus, sweating, injection-site reactions. less commonly: abdominal pain, dyspepsia, dry mouth, dysphagia, taste disturbances, anorexia, constipation, flatulence, cholestasis, hepatic dysfunction, ascites, palpitation, arrhythmia, chest pain, heart failure, thrombophlebitis, flushing, hypotension, hypertension, bronchospasm, cough, dizziness, fatigue, paraesthesia, hypoaesthesia, sleep disturbances, tremor, anxiety, disorientation, hyper glycaemia, renal failure, hypomagnesaemia, hypocalcaemia, metabolic acidosis, anemia, thrombocytopenia, leucopenia, myalgia, muscular weakness, blurred vision, and erythema multiform; also reported, adult respiratory distress syndrome and anaphylaxis.

Dose and Maintenance: By intravenous infusion: 70 mg on first day then 50 mg once daily (70 mg once daily if body-weight over 80 kg).