Indications: tuberculosis in combination with other drugs; adjunct to doxycycline in brucellosis.

Cautions: breast-feeding, increase dose interval in renal impairment.

Contra-indications: pregnancy, myasthenia gravis.

Side Effects: vestibular damage, reversible nephrotoxicity. rarely, hypomagnesaemia on prolonged therapy, antibiotic-associated colitis, stomatitis; also reported, nausea, vomiting, rash, blood disorders.

Pregnancy: Second and third trimester: Auditory or vestibular nerve damage.

Dose: by IM injection, 1 g daily.

In patients over 40 years, under 50 kg or those with renal impairment, reduce dose.

Note: One-hour (peak) concentration should be 15–40 mg/litre; pre-dose (‘trough') concentration should be less than 5 mg/litre (less than 1 mg/litre in renal impairment or in those over 50 years).