Indications: In combination with other drugs, tuberculosis resistant to first-line drugs.

Cautions: auditory impairment; monitor renal, hepatic, auditory, and vestibular function and electrolytes.

Contra-indications: Hypersensitivity to capreomycin or any component of the formulation.

Hepatic impairment use with caution

Renal impairment reduce dose, nephrotoxic; ototoxic.

Pregnancy manufacturer advises use only if potential benefit outweighs risk (teratogenic in animal studies).

Breast-feeding manufacturer advises caution (no information available).

Side Effects: hypersensitivity reactions including urticaria and rashes. leukocytosis or leucopenia, rarely thrombocytopenia. changes in liver function tests nephrotoxicity, electrolyte disturbances hearing loss with tinnitus and vertigo neuromuscular block after large doses. pain and induration at injection site.

Dose: By deep intramuscular injection: 1 g daily (not more than 20 mg/kg) for 2–4 months, then 1 g 2–3 times each week.