Indications: infections due to sensitive Gram-positive and Gram-negative bacteria.

Cautions: penicillin sensitivity; renal impairment; pregnancy and breast-feeding.

Contra-indications: cephalosporin hypersensitivity; porphyria.

Side Effects: allergic reactions including urticaria and rashes, hypersensitivity reactions including anaphylaxis, nausea, vomiting, diarrhoea, false positive results for glucose in urine with reducing substances, reduce also in renal impairment.

Dose: 250 mg every 6 hours or 500 mg every 8-12 hours. In severe infections, 1-1.5 g every 6-8 hours.

child 25 mg/kg daily in divided doses, doubled for severe infections, max. 100 mg/kg daily; or under 1 year 125 mg every 12 hours, 1–5 years 125 mg every 8 hours, 6–12 years 250 mg every 8 hours.

Prophylaxis of recurrent urinary-tract infection, adult 125 mg at night.