Indications: Gram-negative infections including Pseudomonas aeruginosa, Haemophilus influenzae, and Neisseria meningitidis.

Caution: hypersensitivity to beta-lactam antibiotics; hepatic impairment; renal impairment, breast feeding.

Contra-indications: hypersensitivity; pregnancy.

Side Effects: nausea, vomiting, diarrhoea, abdominal cramps; mouth ulcers, altered taste; jaundice and hepatitis; flushing; hypersensitivity reactions; blood disorders (including thrombocytopenia and neutropenia); rashes, injection-site reactions; rarely hypotension, seizures, asthenia, confusion, dizziness, headache, halitosis, and breast tenderness; very rarely antibiotic- associated colitis, gastro-intestinal bleeding, and toxic epidermal necrolysis.

Dose: By deep intramuscular injection or by intravenous injection over 3–5 minutes or by intravenous infusion, 1 g every 8 hours or 2 g every 12 hours; 2 g every 6–8 hours for severe infections (including systemic Pseudomonas aeruginosa and lung infections in cystic fibrosis); single doses over 1 g intravenous route only Urinary-tract infections, 0.5–1 g every 8–12 hours CHILD over 1 week, by intravenous injection or infusion, 30 mg/kg every 6–8 hours increased in severe infections for child of 2 years or older to 50 mg/kg every 6–8 hours; max. 8 g daily Gonorrhoea, cystitis, by intramuscular injection, 1 g as a single dose.