Indications: urinary tract infections, otitis media, sinusitis, chronic bronchitis, invasive salmonellosis, gonorrhoea; endocarditis prophylaxis; Helicobacter pylori eradication.

Cautions: history of allergy; reduce dose in renal impairment; erythematous rashes in glandular fever and chronic lymphatic leukaemia, and possibly HIV infection.

Contra-indications: penicillin hypersensitivity.

Side Effects: nausea, diarrhoea, rash, antibiotic- associated colitis.

Dose: by mouth, 250 mg every 8 hours, doubled in severe infections.

Child up to 10 years, 125 mg every 8 hours.

Severe or recurrent purulent respiratory infection, 3 g every 12 hours.

Dental abscess as a short course, 3 g repeated after 8 hours.

Urinary tract infections, 3 g repeated after 10-12 hours as a short course.

Gonorrhoea, single dose of 2-3 g with probenecid 1 g. Otitis media, child 3-10 years, 750 mg twice daily for 2 days.

Pregnancy: Not known to be harmful

Breast feeding: Trace amounts in milk