It is dopamine agonists.

Indications: used alone or with other medications to treat the symptoms of Parkinson's, it is also used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down).

Cautions: avoid abrupt withdrawal (risk of neuroleptic malignant syndrome), renal impairment, pregnancy, severe cardiovascular disease, psychotic disorders, ophthalmological testing recommended (risk of visual disorders).

Contra- Indications: hypersensitivity to pramipexole or any component of the formulation, breast- feeding.

Side Effects: nausea, abnormal body movements and motions, weakness dizziness drowsiness, difficulty falling asleep or staying asleep, difficulty remembering, confusion, abnormal thoughts, heartburn, constipation, diarrhoea, loss of appetite, weight loss, dry mouth, joint pain, frequent urination or urgent need to urinate, difficulty urinating or pain when urinating, decreased sexual interest or ability, oedema, hallucinations, changes in vision, chest pain, shortness of breath, dark, red, colored urine, muscle tenderness, muscle weakness, postural hypotension.

Dose: Parkinson's disease, initially 0.88 mg 3 times daily, dose doubled every 5-7 days if tolerated to 0.350 mg 3 times daily, further increased if necessary by 0.18 mg 3 times daily at weekly intervals. Max. 3.3 mg daily in 3 divided doses.

When it is used to treat restless legs syndrome, initially 0.88 mg once daily 2-3 hours before bedtime, dose doubled every 4-7 days if necessary to 0.350 mg daily, max. 0.540 mg daily, children and adolescent under 18 years not recommended.

The doses in renal impairment need to be adjusted.