Indications: mild to moderate, pain, pyrexia; antiplatelet.

Cautions: gastro-intestinal ulcers, haemophilia, anticoagulant therapy, asthma, impaired renal or hepatic function, dehydration, pregnancy; elderly; G6PD- deficiency.

Contra-indications: children and adolescents under 16 years and in breast-feeding (Reye's syndrome); previous or active peptic ulceration, haemophilia; not for treatment of gout; history of hypersensitivity to aspirin or any other NSAID.

Interactions: Aspirin interacts significantly with a number of other drugs and its interaction with warfarin is a special hazard,

Side Effects: mild and occasional, high rate of gastro- intestinal irritation with slight asymptomatic blood loss, increased bleeding time, bronchospasm and skin reactions in hypersensitive patients.

Dose: 300-900 mg every 4-6 hours when necessary, max. 4 g daily.

Child and adolescent not recommended.