Indications: severe nausea and vomiting, vertigo, labyrinthine disorders; cytotoxic therapy.

Contra-indications: avoid in children weighing less than 10 kg; elderly.

Dose: by mouth, nausea and vomiting, acute attack, 20 mg initially then 10 mg after 2 hours;

Prevention, 5-10 mg 2-3 times daily;

Child (over 10 kg), 250 mcg/kg 2-3 times daily; Labryinthine disorders, 5 mg 3 times daily, gradually increased if necessary to 30 mg daily in divided doses, then reduced after several weeks to 5-10 daily;

Deep IM injection, 12.5 mg when required followed if necessary after 6 hours by an oral dose.