Domperidone acts at the chemoreceptor trigger zone.. It has the advantage over metoclopramide and the phenothiazines of being less likely to cause central effects such as sedation and dystonic reactions because it does not readily cross the blood-brain barrier. In Parkinson’s disease, it is used to prevent nausea and vomiting during treatment with Domperidone is also used to treat.

Indications: Acute nausea and vomiting especially when associated with cytotoxic therapy, apomorphine and other dopaminergic drugs, emergency hormonal contraception; dyspepsia, gastro-oesophageal reflux.

Cautions: children; renal impairment; breast-feeding; chronic use.

Contra-indications: routine prophylaxis in post- operative vomiting; prolactinoma, hepatic impairment; where increased gastro-intestinal motility harmful; pregnancy.

Side-effects; increased prolactin concentrations; reduced libido; rash; acute dystonic reactions.

Dose: by mouth, acute nausea and vomiting, 10-20mg every 4-8 hours.

Max. period of treatment, 12 weeks.

Child, nausea and vomiting induced by chemo-or radiotherapy only, 200-400 mcg/kg every 4-8 hours. Functional dypepysia, 10-20 mg 3 times daily before food and 10-20 mg at night.

Max. period of treatment, 12 weeks.

Child, body-weight under 15 kg, not recommended.