Indications: treatment of major depressive disorder Cautions: pregnancy Based on animal data, may cause fetal harm Nursing Mothers: Discontinue drug or nursing taking into consideration importance of drug to mother Geriatric Use: There is an increased incidence of orthostatic hypotension in desvenlafaxine treated patients ≥ 65 years.

Contra-indications: Hypersensitivity to desvenlafaxine succinate, venlafaxine hydrochloride or to any excipients. The use of MAOIs intended to treat psychiatric disorders with Desvelafaxine or within 7 days of stopping treatment with Desvelafaxine is contraindicated because of an increased risk of serotonin syndrome. The use of Desvelafaxine within 14 days of stopping an MAOI intended to treat psychiatric disorders is also contraindicated.

Side Effects: nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, and specific male sexual function disorders.

Dose: Recommended dose 50 mg once daily with or without food There was no evidence that doses greater than 50 mg per day confer any additional benefit Discontinuation: Reduce dose gradually whenever possible Take tablets whole; do not divide, crush, chew, or dissolve Moderate renal impairment Max. dose 50 mg per day Severe renal impairment and end-stage renal disease: Max. dose 50 mg every other day Moderate to severe hepatic impairment Max. dose 100 mg per day.