Indications: Schizophrenia

Cautions: Hepatic impairment, correct hypokalemia or hypomagnesaemia befpr treatment, monitor ECG during treatment. monitor blood pressure during dose titration and early maintenance therapy

Contra-indications: Sever hepatic impairment, QT interval prolongation (ECG required before and during treatment uncorrected hypokalaemia and hypomagnesaemia.

Side Effects: Prolonged QT interval, peripheral oedema, dry mouth, rhinitis, nasal congestion, dyspnoae, paraesthesia, abnormal ejaculation (decreased volume), hyperglycaemia

Dose: Initially 4 mg daily increased in steps of 4 mg at intervals of 4-5 days to usual maintenance of 12-20 mg as a single daily dose, max.24 mg daily.

Elderly: consider slow dose titration and lower maintenance dose.

Child and adolescent: not recommended. Serdolect Tablet4 mg, 16mg