Indication: Schizophrenia, mono or combination therapy for mania.

Cautions: Increased risk of stroke in elderly patients with dementia; concomitant administration of drugs that prolong QT intervals; pregnancy; hepatic impairment; renal impairment; cardiovascular disease; history of epilepsy and Parkinson's disease; also prostatic hypertrophy, susceptibility to angle-closure glaucoma, paralytic ileus, diabetes mellitus (risk of exacerbation or ketoacidosis), low leucocyte or neutrophil count, bone- marrow depression, hypereosinophilic disorders, myeloproliferative disease.

Contra-indications: Breast feeding, For injection acute myocardial infarction, unstable angina, severe hypotension or bradycardia, sick sinus syndrome, recent heart surgery.

Side Effect: mild & transient antimuscarenic effects, drowsiness, speech difficulties, exacerbation of Parkinson's disease, abnormal gait, hallucinations, akathisia, asthenia, increased appetite, increased body temperature, increased triglycerides conc. edema, hyperprolactinemia, urinary incontinence; eosinophilia; less commonly hypotension, bradycardia, QT interval prolongation, photosensitivity; rarely seizures, leucopenia, rash; very rarely thromboembolism, hypercholesterolaemia, hypothermia, urinary retention, priapism, thrombocytopenia, neutropenia, rhabdomyolysis, hepatitis, pancreatitis; with injection, injection-site reactions, sinus pause, hypoventilation.

Dose: Schizophrenia, Combination therapy for mania Adult over 18 years 10 mg daily to Max.20 mg daily Monotherapy of mania: 15 mg daily to Max. dose 20 mg daily.