Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.

Indications: short-term treatment in healing and symptomatic relief of duodenal ulcers and erosive or ulcerative gastroesophageal reflux disease (GERD); maintaining healing and reducing relapse rates of heartburn symptoms in patients with GERD; treatment of daytime and nighttime heartburn and other symptoms associated with GERD; long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome and in combination with amoxicillin and clarithromycin to eradicate Helicobacter pylori.

Cautions: Adjust the doses in chronic hepatic function impairment patients.

Precautions: Avoid in pregnancy and breast feeding. Side effect: Headache; insomnia; anxiety; dizziness; depression; nervousness; dry eyes; abnormal vision; Diarrhea; nausea; abdominal pain; vomiting; dyspepsia; flatulence; constipation; dry mouth.

Dose: Healing of Duodenal Ulcers, Adults: orally 20 mg/day after the morning meal for 4 wk, additional therapy may be required for some patients.

Treatment of Erosive or Ulcerative GERD, Adults: orally 20 mg/day for 4 to 8 wk, an additional 8 wk may be considered for patients who do not heal. Maintenance of Erosive or Ulcerative GERD, Adults: orally 20 mg/day. Treatment of Symptomatic GERD, Adults: orally 20 mg once daily for 4 wk. An additional course of treatment may be considered if symptoms do not resolve after 4 weeks.

Treatment of Pathological Hypersecretory Conditions, Adults: orally 60 mg/day. Doses up to 100mg daily or 60 mg twice daily have been administered.

H. Pylori Eradication to Reduce Risk of Duodenal Ulcer Recurrence, Adults: orally 20 mg rabeprazole plus amoxicillin 1, 000 mg plus clarithromycin 500 mg bid for 7 days with morning and evening meals.